Abstract #2515

Cortical alterations after very preterm birth and the association with socio-emotional abilities from childhood to early adolescence

Elda Fischi-Gomez¹, Vanesssa Siffredi^2,3,4, Maria Chiara Liverani⁵, Cristina Borradori-Tolsa^2,5, Russia Hà-Vinh Leuchter⁶, and Petra Susan Hüppi⁶

¹Computer Imaging and Machine Learning, CIBM CHUV-EPFL SP Section, Lausanne, Switzerland, ²Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland, Geneva, Switzerland, ³Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Switzerland, Lausanne, Switzerland, ⁴Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Switzerland, Geneva, Switzerland, ⁵SensoriMotor, Affective and Social Development Laboratory, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland, Geneva, Switzerland, ⁶Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland

Synopsis

Keywords: Adolescents, PediatricThis study compared GM concentration and its developmental trajectory in vey preterm (VPT) and full-term (FT) children aged 6 to 14 years. Widespread abnormal GM concentration was found with complicated patterns of increases/decreases of GM concentration across cortical and subcortical regions. Socio-emotional abilities were association with GM concentration in regions known to be involved in such process for both VPTand FT peers. Our findings suggest the trajectory of brain development following VPT birth may be fundamentally distinctive with impact on socio-emotional abilities.

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