Abstract #2516

Mechanical Properties of Pediatric Central Nervous System Tumors in Children With and Without Neurofibromatosis Type 1

Grace McIlvain¹, Abdulhafeez M Khair², Vinay Kandula², Gurcharanjeet Kaur², Andrew Walter², Lauren Averill², Arabinda K Choudhary², Curtis L Johnson^1,2, and Rahul M Nikam²

¹University of Delaware, Newark, DE, United States, ²Neuroradiology, Nemours Children's Health, Wilmington, DE, United States

Synopsis

Keywords: Neuro, TumorPediatric brain tumors have developmental consequences even when prognoses are favorable. Mechanical characterization using magnetic resonance elastography (MRE) has previously revealed adult gliomas are softer than brain tissue. However, pediatric tumors are known to differ behaviorally and cytoarchitecturally from adult tumors. Neurofibromatosis type 1 (NF1) imparts genetic predisposition to gliomas, but also results in spongiform regions in white matter tissue. Here we use MRE for the first time in NF1 and in pediatric low-grade gliomas and we find that pediatric gliomas are softer than reference tissue, while spongiforms are stiffer.

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