Abstract #2517

Effects of Intensive sensorimotor training following experimental cerebral palsy assessed by advanced diffusion MRI

Yohan van de Looij^1,2, Eduardo Sanches¹, Ho Dini¹, Audrey Toulotte¹, Laetitia Baud³, Quentin Barraud³, Rodrigo Araneda⁴, Yannick Bleyenheuft⁴, Sylvain Brochard^5,6, Gregoire Courtine³, and Stéphane Sizonenko¹

¹Department of Paediatrics and Gynaecology-Obstetrics, Division of Development and Growth, University of Geneva, Geneva, Switzerland, ²Center for Biomedical Imaging, Animal Imaging Technology section, Federal Institute of Technology of Lausanne, Lausanne, Switzerland, ³Center for Biomedical Imaging, Federal Institute of Technology of Lausanne, Lausanne, Switzerland, ⁴Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium, ⁵Physical and medical rehabilitation department, CHRU Brest, Brest, France, ⁶Paediatric physical and medical rehabilitation department, Fondation ILDYS, Brest, France

Synopsis

Keywords: Neonatal, Brain, Cerebral palsy, preclinical animal modelInjury to the developing brain is a major cause of Cerebral Palsy (CP) leading to motor and cognitive disabilities. HABIT-ILE is a 2-week intensive sensorimotor rehabilitation program with proven effects decreasing motor impairments in infants with CP. Here, we combined early environmental enrichment (EE) and treadmill motor training (TT) to model HABIT-ILE (EETT) for treating experimental CP in rats assessing then histological and microstructural parameters (diffusion MRI at 9.4T). Exvivo DTI/NODDI showed altered brain microstructure in CP rats not reversed by HABIT-ILE. HABIT-ILE modulated BDNF signaling and decreased the over-expression of proteins involved in excitatory function induced by CP.

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