Keywords: Neuro, White Matter, DTI , MTIX-linked Pelizaeus Merzbacher disease is characterized by failure of myelin formation and subsequent axonal damage. Severity of disease courses varies depending on the underlying gene mutation. Eight male patients were recruited for the study. MR-imaging protocol included MTI, MWI for evaluation of myelin related parameters and DTI for assessment of axonal integrity. Decreased values in quantitative MTI and MWI parameter maps and ROI analyses indicated severe myelin deficit in all patients. However, FA reflected various degrees of axonal involvement among patients with deferent genotypes. Multimodal MRI can facilitate assessment of simultaneous disease processes in childhood hypomyelinating leukodystrophies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords