Abstract #2525

Efficacy of virtual reality therapy using functional connectivity and structural measures in children with cerebral palsy

S Senthil Kumaran¹, N M Shruthi², Priyanka Bhat³, Sheffali Gulati², and Tapan Kumar Gandhi⁴

¹Department of NMR, All India Institute of Medical Sciences, New Delhi, India, ²Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India, ³Center for BioMedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ⁴Electrical Engineering, Indian Institute of Technology, Delhi, New Delhi, India

Synopsis

Keywords: Neuro, fMRI (task based)Hemiparetic cerebral palsy patients were administered Virtual reality therapy (VRT) in addition to constraint induced movement therapy (CIMT) in VRT group, and CIMT alone in CIMT group in a randomised trial. Task based functional MRI of left and right fist clenching and structural data were acquired in a 3T MR scanner. Cortical thickness, gyrification (using cat12 toolbox) and functional connectivity (using conn toolbox) results revealed presence of salience and motor networks in the VRT group, highlighting better recovery mechanism stimulated by virtual reality based training.

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