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Abstract #2526

Clinical Utility of Optimised Ultra-Low Field Structural MR Brain imaging in Neonates

Paul Cawley1,2,3, Francesco Padormo1,4, Daniel Cromb1,5, Alessandra Maggioni5, Jennifer Almalbis1, Miguel De La Fuente Botell5, Massimo Marenzana1, Rui Teixeira4, UNITY Consortium6, Steve Williams6, Serena Counsell1, Tomoki Arichi1,3, Mary Rutherford1,3, Joseph V Hajnal1, and A David Edwards1,3,5
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Neonatal Intensive Care Unit, Evelina Children's hospital, London, United Kingdom, 3MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom, 4Hyperfine, Inc., Connecticut, CT, United States, 5Neonatal Intensive Care Unit, Evelina Children’s Hospital, London, United Kingdom, 6Centre for Neuroimaging Sciences, King's College London, London, United Kingdom

Synopsis

Keywords: Neuro, Low-Field MRIPerinatal brain injury and congenital brain abnormalities are common. Access to definitive neuro imaging is limited globally, particularly within resource constrained settings, or in infants too sick to transfer to scanning departments. New devices utilising ultra-low field magnets may herald a revolution in lower-cost high-access MRI, but preliminary results using manufacturer standard adult-optimised sequences has produced suboptimal image quality in neonates. We performed optimisation of low field MRI pulse sequence design and demonstrate enhanced visualization of key brain tissues and neuroanatomical structures. Neonatal-specific sequences show promising performance across a range of gestational maturities and perinatal brain abnormalities.

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Keywords