Abstract #2528

Individualised perioperative brain growth in infants with congenital heart disease (CHD): correlation with clinical risk factors

Daniel Cromb^1,2, Alexandra Bonthrone^1,2, Alessandra Maggioni¹, Paul Cawley^1,3, Ralica Dimitrova^1,4, Christopher Kelly¹, Lucilio Cordero-Grande^1,5, Olivia Carney¹, Alexia Egloff-Collado¹, Emer Hughes¹, Joseph V Hajnal^1,2, John Simpson^1,6, Kuberan Pushparajah^1,6, Mary Rutherford^1,3, A David Edwards¹, Jonathan O'Muircheartaigh^1,3,4, and Serena J Counsell^1,2

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom, ⁴Department for Forensic and Neurodevelopmental Sciences, King's College London, London, United Kingdom, ⁵Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid and CIBER-BBN, Madrid, Spain, ⁶Paediatric Cardiology, Evelina London Children's Hospital, London, United Kingdom

Synopsis

Keywords: Neuro, Brain, CardiovascularInfants with congenital heart disease (CHD) are at risk of neurodevelopmental impairments, which may be associated with impaired brain growth. We mapped brain volumes from pre- and postoperative brain MRI in 36 infants with CHD undergoing cardiac surgery or intervention to normative curves derived from 219 healthy infants. Perioperative brain growth was impaired, and was associated with clinical and surgical risk factors, including higher preoperative serum creatinine levels, older postnatal age at surgery, longer cardiopulmonary bypass duration and longer postoperative intensive care stay. Brainstem and deep grey matter growth appear particularly vulnerable to clinical factors.

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