Abstract #2529

Cerebrospinal fluid as a zero reference regularization for functional quantitative susceptibility mapping

Chang-Jin Huang¹, Hong-Yi Wu¹, Changwei Wu², Shen-Mou Hsu³, and Jyh-Hong Chen⁴

¹Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ²Research Center for Brain and Consciousness, Taipei Medical University, Taipei, Taiwan, ³Imaging Center for Integrated Body, Mind and Culture Research, National Taiwan University, Taipei, Taiwan, ⁴Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

Synopsis

Keywords: Data Analysis, Quantitative Susceptibility mappingFunctional quantitative susceptibility mapping (fQSM) providing complementary quantitative information for fMRI, has been applied to study brain functions. However, the sensitivity of fQSM suffers from the QSM reconstruction, especially solving an ill-posed deconvolution. To improve the sensitivity of fQSM, we first applied MEDI+0 in fQSM study. This method using cerebrospinal fluid as a zero reference regularization has been proven to reduce the variability of the susceptibility maps from rescan. The higher common voxel ratio and cosine similarity scores were obtained by MEDI+0 than by MEDI. Activated voxels were successfully detected by MEDI+0 during high cognition task from standard fMRI acquisition.

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