Abstract #2545

A consensus Protocol for task-free Anesthetized Rat functional Magnetic Resonance Imaging and Data Analysis

Roël Matthijs Vrooman¹, Gabriel Desrosiers-Gregoire^2,3, Gabriel Devenyi^2,4, Yen-Yu Ian Shih^5,6,7, Sung-Ho Lee^5,6, Monica van den Berg^8,9, Georgios Keliris^8,9, and Joanes Grandjean^1,10

¹Donders Institute for Brain, Cognition and Behaviour, RadboudUMC, Utrecht, Netherlands, ²Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada, ³Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada, ⁴Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁵Center for Animal MRI, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁶Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁷Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁸Bio-imaging lab, University of Antwerp, Antwerpen, Belgium, ⁹µNEURO Research Centre of Excellence, University of Antwerp, Antwerpen, Belgium, ¹⁰Department for Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands

Synopsis

Keywords: Data Acquisition, fMRI (resting state), Rat, RodentfMRI in rats is performed under diverse protocols that span different animal handling practices and preprocessing steps. The disparity in image acquisition and preprocessing hampers the interoperability and comparison of the results between studies. Importantly, it is unclear what factors lead to superior acquisition and detection of functional networks. We detail a consensus-based task-free fMRI acquisition protocol in the rat that has been validated in 21 datasets. Along with the animal handling protocol and MRI sequence, we provide a detailed path for data conversion, preprocessing, and analysis.

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