Abstract #2568

7T spin-echo dynamic susceptibility contrast MRI to assess cerebral microvascular perfusion

Elles P. Elschot^1,2, Marieke van den Kerkhof^1,2, Robert J. van Oostenbrugge^2,3,4, Abraham A. Kroon^4,5, Walter H. Backes^1,2,4, and Jacobus F. A. Jansen^1,2,6

¹Radiology & Nuclear Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, ²School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ³Neurology, Maastricht University Medical Center +, Maastricht, Netherlands, ⁴School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands, ⁵Internal Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, ⁶Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Synopsis

Keywords: Contrast Mechanisms, PerfusionUltra-high-field exploits the possibilities of MRI techniques, which are less sensitive at lower field strength, such as spin-echo (SE) perfusion MRI. We assessed the feasibility of SE dynamic susceptibility contrast MRI at 7T and investigated the ability to measure variations in perfusion in an elderly, partially hypertensive, population (n=36). Microvascular cerebral blood flow (CBF) was higher in grey matter compared to white matter, corresponding with biological expectations, serving as a first validation step. Furthermore, CBF significantly decreased with age.

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