Abstract #2570

Age dependent changes of water exchange rate across the blood-brain barrier (BBB) in 115 subjects with age ranging from 8 to 87 years

Xingfeng Shao¹, Qinyang Shou¹, Kimberly Felix², Brandon Ojogho¹, Xuejuan Jiang^2,3, Brian T. Gold⁴, Megan M. Herting², and Danny JJ Wang¹

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ³Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁴Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, United States

Synopsis

Keywords: Arterial spin labelling, Permeability, BBB water exchange, permeability, ageingWe studied age-related BBB water exchange rate (kw) changes in a wide range of age groups with 115 subjects using diffusion prepared pseudo-continuous arterial spin labeling (DP-pCASL). We observed a significant trend of decreasing kw with age (slow when ≤50 years old and fast when >50 years old) and large spread of kw values in subjects >50 years, which may indicate compromised BBB function in some ageing populations. The inverted U-shaped correlations between kw versus age suggest a more complex age dependent changes in hippocampus and PHG regions.

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