Abstract #2575

APOE genotype-dependent sex differences in cortical hemodynamics measured with arterial spin labeling MRI

Nikou Louise Damestani^1,2, John Jacoby¹, Barnaly Rashid^1,3, Allison E Lovely¹, Shrikanth M Yadav¹, Aurea Michael¹, Marziye Eshghi⁴, Melissa Terpstra⁵, Carlos Cruchaga^6,7,8, David H Salat^1,2,9, and Meher R Juttukonda^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Neurology, Harvard Medical School, Boston, MA, United States, ⁴MGH Institute of Health Professions, Boston, MA, United States, ⁵MU School of Medicine, University of Missouri, Columbia, MO, United States, ⁶Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States, ⁷NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, United States, ⁸Hope Center for Neurologic Diseases, Washington University, St. Louis, MO, United States, ⁹Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, United States

Synopsis

Keywords: Arterial spin labelling, AgingIdentifying biomarkers that could characterize typical from atypical aging is crucial for understanding the aging process. One of the most significant genetic risk factors for Alzheimer’s Disease, an age-related neurodegenerative disorder, is the presence of an apolipoprotein-E (APOE) ε4 allele. Here, we investigate the impact of APOE genotype on cortical hemodynamics in a large cohort of participants across the lifespan, accounting for interacting effects of age, sex, and cardiovascular risk. We found unique spatial patterns of cerebral blood flow and arterial transit time between males and females within distinct APOE genotypes, potentially indicating the presence of a complex interaction.

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