Abstract #2576

The ASL Challenge Reproduction Study: Replicating Findings from The OSIPI-ISMRM ASL MRI Challenge

Channelle Tham¹, Ahmed Abdalle², Joseph G Woods³, Maria-Eleni Dounavi⁴, Andre Pascoal⁵, and Udunna Anazodo⁶

¹Department of Cognitive Neuroscience, Radboud University, Nijmegen, Netherlands, ²Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Wellcome Centre for Integrated Neuroimaging, FMRIB, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom, ⁴Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, ⁵Instituto de Radiologia e Departamento de Radiologia e Oncologia, University of Sao Paulo, Sao Paulo, Brazil, ⁶Montreal Neurological Institute, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Arterial spin labelling, Challenges, ReproducibilityWhile the recommendation for ASL acquisition is widely adopted to standardize quantification of cerebral blood flow (CBF), ASL analysis still produces wide variability in CBF estimates. The recent OSIPI-ISMRM ASL MRI Challenge highlighted how differences in image processing contribute to CBF variability. Here, we explored the replicability of ASL image processing approaches when used as documented to quantify CBF. The results of 5 of the 8 ASL Challenge teams were replicated and compared to their submitted results. The overall errors in global mean CBF were 0.03-5 times larger in the replicated results, demonstrating the need for ASL analysis standards.

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