Abstract #2581

Detectability of changes in the blood-brain barrier permeability to water using optimised multi-TE pseudo-continuous arterial spin labelling

Logan X. Zhang^1,2 and Michael Chappell^1,3

¹Sir Peter Mansfield Imaging Centre and Mental Health & Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ²Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom, ³Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Synopsis

Keywords: Arterial spin labelling, Arterial spin labellingThe blood-brain barrier integrity can be reflected by the pre-exchange lifetime of water molecules, Tex, which can be measured using multi-TE multi-delay ASL. Nevertheless, the low SNR of ASL limits the detectability of subtle Tex changes within a feasible scan time for clinical applications. In this study, optimised protocols were evaluated for the theoretical detectability of 10% changes in haemodynamic parameters. Simulation shows that while changes in CBF and arterial transit time (ATT) could be detected on individual level in a five-minute scan, the same detectability of Tex would require a minimum of 6 subjects within ten minutes of scanning.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.