Abstract #2584

Evaluation of 3D Stack-of-Spiral Turbo FLASH Acquisitions for PCASL- and VSASL-Derived Brain Perfusion Mapping

Dan Zhu^1,2, Feng Xu^1,2, Dapeng Liu^1,2, Doris Lin², Peter van Zijl^1,2, and Qin Qin^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Arterial spin labelling, Arterial spin labellingThe most-used 3D acquisition for ASL at 3T is GRASE or stack-of-spiral (SOS) based FSE, which requires multiple shots to cover the full k-space. Alternatively, turbo FLASH (TFL) acquisition allows longer echo trains with slower T₁ (than T₂) relaxation, and 3D SOS-TFL has the potential to reduce the number of shots to even single-shot, thus improving the temporal resolution for ASL. Here we demonstrated comparable performance of 3D SOS-TFL with 3D GRASE on PCASL- and VSASL-derived CBF mapping and VSASL-derived CBV mapping at 3T on 12 healthy subjects, and the utility of 3D SOS-TFL on a stroke patient.

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