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Abstract #2588

Phase contrast motor unit MRI (PC-MUMRI) to investigate changes to muscle twitch dynamics in a healthy ageing cohort

Matthew G. Birkbeck 1,2,3, Linda Heskamp1, Ian S. Schofield1, Julie Hall4, Roger G. Whittaker1, and Andrew M. Blamire1
1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, 2NIHR Biomedical Research Centre, NIHR Biomedical Research Centre, Newcastle upon Tyne, United Kingdom, 3Northern Medical Physics and Clinical Engineering, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 4Department of Neuroradiology, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

Synopsis

Keywords: Muscle, AgingFunctional changes to the muscle’s contractile and relaxation properties occur with age. Current techniques which measure twitch dynamics provide limited information about individual muscles. We used phase contrast motor unit MRI (PC-MUMRI) to non-invasively measure the contraction and relaxation times of lower leg muscles in a healthy ageing cohort, relating this to isometric maximum voluntary contraction (MVC). Contraction and relaxation times increased with ageing and were negatively correlated with MVC. PC-MUMRI offers a sensitive method to measure muscle twitch dynamics and could be combined with other MR techniques to characterise functional changes to muscle with ageing.

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