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Abstract #2592

Multi-parametric measures of in-vivo T2* mapping with δUTE and macromolecule exchange ZAP/CEST of cartilage, tendon, and muscle tissue in foot.

Vadim Malis1, Won Bae1,2, Diana Vucevic1, Yoshimori Kassai3, and Mitsue Miyazaki1
1Radiology, UC San Diego, San Diego, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States, 3Canon Medical, ƌtawara-shi, Japan

Synopsis

Keywords: Tendon/Ligament, CEST & MT, UTE, Ultra-short TEA δUTE sequence allows for collecting multiple echoes with short echo time intervals, without the restriction of in-phase TEs. This study utilizes data collected with δUTE for bi-exponential T2* mapping of cartilage, muscle and tendon tissues in a human foot. The same anatomies are also evaluated using Z-spectrum Analysis Protons (ZAP) and Chemical exchange saturation transfer (CEST). While ZAP imaging provides overall exchange proton quantification of free and restricted exchange protons in a wide range of frequencies, CEST focuses on specific hydroxy (-OH, at 1.0 ppm), amine (-NH2, at 2 ppm), and amide (-NH, at 3.5 ppm) protons.

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Keywords