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Abstract #2593

Feasibility of high-resolution multi-shot DW-EPI for DTI of peripheral nerves in the knee

Daehyun Yoon1, Brian Hargreaves1, and Amelie Lutz1
1Radiology, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Neurography, Diffusion Tensor Imaging, Multi-shot DW-EPI, repeatability, feasibilityDTI of peripheral nerves for detecting nerve damage has been very challenging due to limited resolution and imaging artifacts of the conventional single-shot diffusion-weighted echoplanar imaging (SS-DW-EPI). Here, we have evaluated the feasibility of improved DTI with multi-shot DW-EPI (MUSE) by comparing mean diffusivity (MD) and fractional anisotropy (FA) estimates of tibial and peroneal nerves with those from SS-DW-EPI in ten healthy subjects. MUSE showed lower within-subject coefficient of variation in diffusion estimates, indicating improved repeatability, while correlation analysis showed noticeable differences between FA estimates. Our results show the feasibility of MUSE for in vivo evaluation of peripheral nerves.

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Keywords