Abstract #2596

Decipher the simultaneous progress of fat infiltration and muscle atrophy with fat-clustering analysis of MRI

Xin Mu¹, Huahui Xu², Jialin Wang³, Chang Ni¹, Meng Tian⁴, Xiaoli Gu², and Jeff L Zhang¹

¹Vascular and Physiologic Imaging Research (VPIR) Lab, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, ²Department of Radiology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai, China, ³Central Research Institute, UIH Group, Central Research Institute, UIH Group, Shanghai, China, ⁴School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Synopsis

Keywords: Osteoarthritis, AgingFat content and clustering are linked to muscle function in various disorders and are of therapeutic importance because they reflect the physical activity. Thus, we studied the fat content and clustering in three groups: hip-joint replacement surgery (HJRS) patients, ankylosing spondylitis (AS) patients who received medicine, and healthy controls. Although the intramuscular fat of unaffected side remained same in HJRS patients, Moran's index declined. Meanwhile, the Moran index of HJRS patients' affected side decreased significantly when fat content decreased. Besides, the drug treatment for AS patients resulted in a decrease in both fat content and Moran's index.

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