Abstract #2601

T1rho Dispersion in Proteoglycan-depleted Swine Spine Disc

Mitchell J. Christiansen^1,2, Mark C. Preul³, Steven Marsh³, Jay D. Turner⁴, Juan Uribe⁴, Muhammad Nadeem², Elliott J. Mufson², Richard D. Dortch², John C. Gore⁵, and Ping Wang²

¹Creighton University School of Medicine, Phoenix, AZ, United States, ²Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States, ³Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, United States, ⁴Sonntag Spine Center, Barrow Neurological Institute, Phoenix, AZ, United States, ⁵Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Science, Nashville, TN, United States

Synopsis

Keywords: MSK, Degenerative, Intervertebral discT1rho imaging has been used to probe relatively slow macromolecular processes, making it a practical tool to gain information about water spin dynamics and interactions with endogenous macromolecules. We measured the dispersion of T1rho with different spin-lock fields in the intervertebral disc of swine spine specimens before and after the treatment to induce proteoglycan loss, a sign of early disc degeneration. Analysis revealed elevated T1rho values in all proteoglycan-depleted discs at each spin-lock field, and that post-treatment T1rho changes increase at a higher spin-lock field.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.