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Abstract #2608

Geometric mean T2 of the intra/extracellular water can help identify diffusely abnormal white matter in multiple sclerosis

Irene Margaret Vavasour1,2, Kyle Vavasour3, Adam Dvorak4, Tigris Joseph2,4, Robert Carruthers5, Shannon Kolind1,2,4,5, Alice Schabas5, Ana-Luiza Sayao5, Virginia Devonshire5, Roger Tam1,6, GR Wayne Moore2,5,7, Anthony Traboulsee5, David Li1,5, and Cornelia Laule1,2,4,7
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, 3University of British Columbia, Vancouver, BC, Canada, 4Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 5Medicine, University of British Columbia, Vancouver, BC, Canada, 6School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 7Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, diffusely abnormal white matter, T2 relaxationDiffusely abnormal white matter (DAWM) is seen on 25-50% of conventional brain MRI scans from all stages of multiple sclerosis (MS). From 8 advanced MRI metrics, geometric mean T2 of the intra/extracellular water (IET2) best separated MS participants with and without DAWM. Comparing IET2 to controls using z-scores, regions with an intermediate increase in IET2 (z-scores between 1-2) may identify DAWM voxels.

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