Keywords: Dementia, Diffusion/other diffusion imaging techniques, Free water mappingThis study was to evaluate the neuroinflammation-related characteristics of the deep gray matter using free-water mapping in small vessel disease over 1-2 years. Our results support the presence of elevated free water at the preclinical stage of small vessel disease, which remains persistent during the early course of the illness. The free water values changes might be the biomarkers for the mechanism of cognitive decline in the evolution of small vessel disease.
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