Abstract #2610

Assessment of the effects of coronary artery disease on brain oxygen extraction fraction using quantitative susceptibility mapping.

Ali Rezaei^1,2, Stefanie A Tremblay^1,2, Dalia Sabra^1,2,3,4, Safa Sanami^1,2, Brittany Intzandt⁵, Julia Huck¹, Zacharie Potvin-Jutras^1,2, Christine Gagnon², Amelie Mainville-Berthiaume⁶, Lindsay N Wright^1,2, Dajana Vuckovic⁷, Josep Iglesies-Grau^2,8, Thomas Vincent², Mathieu Gayda², Anil Nigam², Louis Bherer^2,8,9, and Claudine J Gauthier^1,2

¹Physics Department, Concordia University, Montreal, QC, Canada, ²Centre Epic and Research Center, Montreal Heart Institute, Montreal, QC, Canada, ³Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada, ⁴PERFORM Centre, Concordia University, Montreal, QC, Canada, ⁵BrainLab, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁶Department of Psychology, Concordia University, Montreal, QC, Canada, ⁷Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada, ⁸Department of Medicine, Université de Montreal, Montreal, QC, Canada, ⁹Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada

Synopsis

Keywords: Blood vessels, Oxygenation

Here we investigated the effect of coronary artery disease (CAD) on the brain oxygen extraction fraction (OEF) using quantitative susceptibility mapping (QSM). Our results, in a pilot dataset, show that OEF was significantly higher in CAD patients than in healthy controls in the caudate nucleus. This may be the result of declining cerebrovascular health in CAD patients in this region. However, since the caudate nucleus is iron-rich, this difference may also be interpreted as iron deposition as CAD has a known neuroinflammatory effect. Future work will investigate the impact of CAD on other metabolic and vascular components of brain health.

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