Abstract #2613

Microstructural alterations in gray and white matter integrity in migraine with aura

Kyla Ann Gaudet¹, Laleh Eskandarian¹, Melanie Li², Susie Y Huang¹, and Katharina Eikermann-Haerter³

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, ³Division of Neuroradiology, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Gray Matter, NeuroinflammationMigraine is one of the most common neurological disorders. Thirty percent of migraine patients develop transient neurological symptoms, the so-called migraine aura. Migraineurs, particularly those with aura, show an increased incidence of white matter lesions (WML). To improve our understanding of WML in migraineurs, we utilized Soma and Neurite Density Image (SANDI) as an advanced diffusion magnetic resonance imaging signal model to assess in-vivo microstructure of gray matter and white matter. We found evidence for occult changes in microstructural gray and white matter integrity that point to a common underlying mechanism driving cellular inflammation and neuronal injury in migraine.

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