Abstract #2615

Change in thalamic cerebrospinal fluid fraction over the adult lifespan and correlation with TSPO PET imaging in multiple sclerosis patients

Thanh D. Nguyen¹, Liangdong Zhou¹, Yeona Kang², Emily Demmon¹, Michael Sakirsky¹, Elizabeth M. Sweeney³, Yi Wang¹, Yi Li¹, and Susan A. Gauthier¹

¹Weill Cornell Medicine, New York, NY, United States, ²Howard University, Washington, DC, United States, ³University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Multiple Sclerosis, NeurofluidsWe applied FAST-T2 multi-component T2 relaxometry to 200 MS patients and 66 healthy controls and found that the thalamic cerebrospinal fluid fraction (CSFF) increases with age and follows a different trajectory in MS. In 13 MS patients, we also found a strong correlation between CSFF and [¹¹C]PK11195 uptake on PET in the thalamus and putamen, suggesting a connection between glymphatic dysfunction and microglial inflammation in the MS brain.

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