Abstract #2618

Deep multiple sclerosis lesion phenotyping using multimodal quantitative MRI

Giacomo Boffa¹, Simona Schiavi¹, Francesco Tazza¹, Caterina Lapucci², Gian Franco Piredda^3,4,5, Domenico Zacà⁶, Luca Roccatagliata⁷, Tom Hilbert^3,4,5, Tobias Kober^3,5,8, Matilde Inglese¹, and Mauro Costagli^1,9

¹Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy, ²Laboratory of Experimental Neurosciences, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, ³Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ⁴Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁵LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁶Siemens Healthcare, Milan, Italy, ⁷Department of Neuroradiology, Health Sciences, University of Genoa, Genoa, Italy, ⁸Lausanne University Hospital and University of Lausanne, Department of Radiology, Luasanne, Switzerland, ⁹IRCCS Stella Maris, Pisa, Italy

Synopsis

Keywords: Multiple Sclerosis, Multi-ContrastQuantitative MRI has the potential to disentangle the heterogeneity of multiple sclerosis (MS) lesions in vivo, which can be decisive for treatment and monitoring. In this study, we distinguished different types of MS lesions based on quantitative susceptibility mapping (QSM) and characterized them using T1 relaxometry, diffusion imaging and myelin mapping. We identified four types of lesions (hypo/isointense, homogeneous hyperintense, inhomogeneous hyperintense and paramagnetic rim), which were characterized by increasing degrees of axonal and myelin disruption. Paramagnetic rim lesions were closer to the ventricular CSF, corroborating the presence of a noxious activity of CSF in MS pathology.

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