Abstract #2619

Enlarged choroid plexus volume in multiple sclerosis is related with disability, cognition and brain atrophy

Samantha Noteboom¹, Jelle J. Vellema¹, Martijn D. Steenwijk¹, Helga E. de Vries², Frederik Barkhof^3,4, Joep Killestein⁵, Eva M. M. Strijbis⁵, and Menno M. Schoonheim¹

¹MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands, ²Department of Molecular Cell Biology and Immunology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands, ³MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands, ⁴Institutes of Neurology and Healthcare Engineering, UCL London, London, United Kingdom, ⁵MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands

Synopsis

Keywords: Multiple Sclerosis, Neuroinflammation

Enlargement of the choroid plexus (ChP) has been recently suggested in multiple sclerosis (MS), but relations with clinical and MRI outcome measures remain unclear. In this study, we compared automated segmentation approaches to assess ChP volume on 3D-T1 to manual outlines. Next, ChP volume was assessed in 327 patients with MS and 78 healthy controls. Gaussian Mixture Modelling (GMM)-based segmentation showed best agreement with manual segmentations in MS and controls. Enlargement of ChP was observed in MS compared to controls, and was associated with worse physical disability and cognitive impairment and more severe brain, cortical and thalamic atrophy.

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