Abstract #2620

Examining T2* Relaxometry in Diffusion Tensor Space to Quantify Cerebral Microbleeds in Alzheimer’s Disease Mouse Model

Emani Hunter¹, Lesley Foley², Yifan Zhao¹, Howard Aizenstein^1,3, Minjie Wu^1,3, and Bistra Iordanova¹

¹Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ²Animal Imaging Center, University of Pittsburgh, Pittsburgh, PA, United States, ³Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States

Synopsis

Keywords: Alzheimer's Disease, Relaxometry, Diffusion Tensor ImagingCerebral microbleeds are morphologic changes contributing to the progression of Alzheimer’s Disease and vascular dementias. However, the effects of microbleeds on brain connectivity across age and sex remain to be understood. In this study, we performed T2* mapping, that was registered to a DTI space to measure diffusion changes in microbleed locations. R2* and diffusion tensor indices demonstrate an inverse relationship, where diffusion is low and R2* rates are high. Our results suggest that microbleeds decrease water diffusion in the brain possibly due to increased neuroinflammation and hemosiderin accumulation, shedding light on abnormal tissue structure in Alzheimer’s disease subjects.

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