Abstract #2623

Longitudinal quantitative MRI changes in normal-appearing brain tissue of patients with multiple sclerosis

Alessandro Cagol^1,2,3, Mario Ocampo-Pineda^1,2,3, Lester Melie-Garcia^1,2,3, Po-Jui Lu^1,2,3, Muhamed Barakovic^1,2,3, Matthias Weigel^1,2,3,4, Xinjie Chen^1,2,3, Antoine Lutti⁵, Thanh D. Nguyen⁶, Yi Wang⁶, Jens Kuhle^2,3, Ludwig Kappos^1,2,3, and Cristina Granziera^1,2,3

¹Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ²Department of Neurology, University Hospital Basel, Basel, Switzerland, ³Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, ⁴Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland, ⁵Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁶Department of Radiology, Weill Cornell Medical College, New York, NY, United States

Synopsis

Keywords: Multiple Sclerosis, Quantitative ImagingWe explored the value of multiple longitudinal quantitative MRI (qMRI) measures in detecting microstructural changes occurring in normal-appearing tissue of patients with multiple sclerosis (PwMS). While no differences in qMRI longitudinal changes were measured between PwMS and healthy controls, progressive PwMS showed accelerated T1-relaxometry increase in normal-appearing tissue with respect to both healthy controls and relapsing-remitting PwMS, reflecting increased micro/macrostructural damage. In PwMS the rates of qMRI changes during follow-up were associated with the severity of clinical disability, with higher neurological impairment being associated with qMRI changes reflecting accelerated micro/macrostructural damage, demyelination, and axon/dendrite loss.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.