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Abstract #2625

MRI characterization of a mouse model of Staphylococcus aureus infection

Hannah Goldman1, Katherine Le2, Orlando Aristizabal1, Matias Aristizabal1, Mia Weissman1, Victor Torres2, and Youssef Zaim Wadghiri1
1Radiology, NYU Langone Health, New York, NY, United States, 2Microbiology, NYU Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Infectious disease, PreclinicalStaphylococcus aureus is of particular concern due to the deaths associated with antimicrobial resistance and the emergence of antibiotic-resistant strains. There is not currently a vaccine as translation from preclinical models to humans has been unsuccessful. Acquiring reproducible and comparable spinal images that offer non-invasive visualization of the extent and impact of the infection are important for successful intervention or vaccine development. 3D-printed, MRI-compatible cradles enable reproducible positioning and analysis for both in vivo and ex vivo MR spinal imaging in mouse models while allowing for nondestructive analysis of the potential additional benefits to visualization associated with ex vivo MEMRI.

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Keywords