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Abstract #2626

The effects of magnetization transfer on fast and slow diffusion compartments in myelinated white matter

Chenyang Li1,2, Els Fieremans1, Dmitry S. Novikov1, and Jiangyang Zhang1
1Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, 2Vilcek Institute of Graduate Biomedical Sciences, NYU Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: White Matter, Contrast MechanismsMyelin, although not directly visible in conventional diffusion MRI (dMRI) due to its short T2, still affects the dMRI signal indirectly through exchange processes with nearby water compartments. In this study, we investigated how a magnetization transfer (MT) preparation affects dMRI signals, in particular, the fast and slow diffusion compartments in myelinated white matter of ex vivo mouse brain. Our result demonstrated that the MT preparation altered the volume fractions, but not the diffusivities, of the fast and slow compartments. Examining the change in volume fractions with MT preparation can provide insights into exchange processes involving myelin and water compartments.

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Keywords