Abstract #2627

The myelin water imaging transcriptome: myelin water fraction regionally varies with genes associated with oligodendrocytes

Jaimie Lee^1,2, Hanwen Liu³, Cornelia Laule^2,4,5,6, Catrina Loucks^1,7,8, and John Kramer^1,2

¹Department of Pharmacology, Anesthesiology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ³Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴Department of Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁷Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁸BC Children's Hospital Research Institute, Vancouver, BC, Canada

Synopsis

Keywords: White Matter, Relaxometry, myelin, transcriptome, myelin water fraction, myelin water imaging, gene expression, microstructureOur objective for this study was to determine the relationship between regional variations in myelin water imaging (MWI) and gene expression – a “MWI transcriptome”. Regional variations in myelin water fraction (MWF) from a normative MWF atlas were examined in a correlation analysis with gene expression data retrieved from the Allen Human Brain Atlas. Genes that significantly covaried with MWF were involved in lipid metabolism and binding, and were enriched for myelin terms (e.g., oligodendrocytes). This preliminary work highlights the utility of an imaging transcriptomic approach and further supports MWI as a robust in vivo measure of myelin.

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