Abstract #2631

Associations between gait speeds and myelin content in cognitively unimpaired adults using multicomponent relaxometry

Mary E. Faulkner¹, John P. Laporte¹, Elango Palchamy², Zhaoyuan Gong¹, Curtis Triebswetter¹, Matthew Kiely¹, M.A.B.S. Akhonda¹, Luigi Ferrucci², Richard G. Spencer¹, and Mustapha Bouhrara¹

¹Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, United States, ²Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, United States

Synopsis

Keywords: White Matter, RelaxometryAbnormal gait speed is a reliable indicator of the progression of age-related neurodegenerations. However, the association between gait speed and myelin content remains unclear. We used multicomponent MR relaxometry of myelin water fraction (MWF) and longitudinal and transverse (R₁ and R₂) relaxation rates to investigate the association between cerebral myelination and usual or rapid gait speeds in cognitively unimpaired adults spanning a wide age range. Our results indicate that lower myelin content is associated with lower gait speed across several while matter structures.

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