Abstract #2637

Alterations in white matter integrity of the pain modulatory system in patients with fibromyalgia

Yu-Ting Huang¹, Ting-Chun Lin², Yao-Wen Liang², You-Yin Chen^2,3, Jiunn-Horng Kang^4,5,6, and Yu-Chun Lo³

¹Department of Medicine, Taipei Medical University, Taipei, Taiwan, ²Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, ³Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ⁴College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ⁵Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan, ⁶Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei, Taiwan

Synopsis

Keywords: White Matter, Diffusion Tensor ImagingThe relationship between abnormal pain sensation and alterations in the central nervous system of fibromyalgia patients is unknown. In this study, diffusion tensor imaging was used to systematically investigate the alterations in white matter tracts of the pain modulatory pathways. The findings revealed the altered integrity of spinothalamic tract-thalamus, thalamus-insula tracts, tracts connected thalamus, midbrain and pons, were associated with the physical and psychological dysfunction in patients with fibromyalgia.

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