Abstract #2640

THE RELATIONSHIP BETWEEN VASCULAR REACTIVITY AND MICROSTRUCTURAL WHITE MATTER INTEGRITY IN DUTCH-TYPE CEREBRAL AMYLOID ANGIOPATHY

Manon Roxanne Schipper¹, Naomi Vlegels^2,3, Sabine Voigt^1,4, Thijs W. van Harten¹, Alberto de Luca^2,5, Ingeborg Rasing⁴, Geert Jan Biessels², Matthias J.P. van Osch¹, Marianne A.A. van Walderveen¹, and Marieke J.H. Wermer⁴

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands, ³LMU Klinikum, München, Germany, ⁴Neurology, Leiden University Medical Center, Leiden, Netherlands, ⁵Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: White Matter, Diffusion Tensor Imaging, PSMDVascular reactivity is an early marker of Cerebral Amyloid Angiopathy (CAA), but its relation to structural brain damage remains unclear. We aimed to study this relationship in Dutch-type CAA (D-CAA; genetic form of CAA): vascular reactivity and microstructural white matter integrity were studied through visually stimulated fMRI and ‘Peak width Skeletonized Mean Diffusivity (PSMD)’. Reduced BOLD amplitude, delayed time to peak, and delayed time to baseline were significantly related to a higher PSMD (β=-1.15e-02, β =1.08e-05, β=8.64e-06, respectively). These results indicate that vascular reactivity and microstructural white matter integrity may deteriorate hand-in-hand in D-CAA.

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