Abstract #2641

Remodeling of White Matter Caused by Sickle Cell Disease

Clio Gonzalez-Zacarias¹, SoYoung Choi², Anand A. Joshi¹, Richard M. Leahy¹, and John C. Wood³

¹Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ²Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Department of Pediatrics and Radiology, Children's Hospital Los Angeles, USC, Los Angeles, CA, United States

Synopsis

Keywords: White Matter, Diffusion/other diffusion imaging techniques, Sickle Cell DiseaseSickle cell disease (SCD) is characterized by the presence of different degrees (mild, moderate, or severe) of chronic anemia (quantified by hemoglobin values). Alterations in WM were assessed by performing a voxel-wise analysis in the fractional anisotropy (FA, i.e., overall directionality of water diffusion), mean diffusivity (MD) and their kurtosis analogous (FAK and MK) maps. Surprisingly, when controlling for log-age, sex and hemoglobin, MK showed bigger derangements in the watershed areas than other measurements like FA and FAK despite of controlling for Hb measurements.

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