Abstract #2643

Two clinically feasible myelin water imaging methods (MCR-DIMWI and METRICS) can differentiate patients with a leukodystrophy from controls.

Menno D Stellingwerff¹, Murtadha L Al-Saady¹, Kwok-Shing Chan², Adam Dvorak³, José P Marques², Shannon Kolind³, Marjo S van der Knaap¹, and Petra JW Pouwels⁴

¹Department of Pediatric Neurology, Amsterdam UMC, Amsterdam, Netherlands, ²Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ³Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁴Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands

Synopsis

Keywords: White Matter, Genetic Diseases, Leukodystrophy

Imaging biomarkers are needed for studying white matter (WM) diseases. Myelin water imaging (MWI) uses multi-compartment relaxometry to estimate myelin content, and is promising for use in leukodystrophies. We applied MCR-DIMWI and METRICS, two novel whole-brain MWI techniques, to a cohort of 9 leukodystrophy patients and 15 controls. Myelin water fractions (MWFs) from both techniques correlated well. In patients, MWF was decreased. For both techniques region-specific MWFs and relaxation metrics could differentiate patients from controls. They are promising for use in the context of leukodystrophies; additional studies are required to further explore potential clinical application.

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