Abstract #2644

Quantification of myelination in Children with Attention-deficit/hyperactivity Disorder: A Comparative Assessment with Synthetic MRI and DTI

liping lin¹, Yingqian chen¹, Yan Dai¹, yan zi¹, Mengsha zou¹, Long qian², Meina Liu³, Hongyu zhang³, Zhiyun yang¹, and Shu su¹

¹Department of Radiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ²Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, Beijing, China, ³Department of Pediatric, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China

Synopsis

Keywords: White Matter, White Matter, attention-deficit/hyperactivity disorder, Synthetic MRI, myelin volume fraction, myelin volume, diffusion tensor imaging, Children.Evaluation of myelin content is crucial for attention-deficit/hyperactivity disorder (ADHD) and other neurodevelopmental disorders. Diffusion tensor imaging (DTI) is a usual tool to assess white matter structural change in ADHD but it’s indirectly. Synthetic MRI–based (SyMRI-based) method, as a suitable quantitative technique, can investigate myelin content through quantifying whole-brain myelin volume fraction (MVF) and myelin volume (MYV). We aim to evaluate myelin estimation using SyMRI–based method and compared it with established DTI metrics in ADHD children.

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