Abstract #2645

Quantitative synthetic MRI reveals white matter alterations in patients with beta-thalassemia

Xi Deng¹, Meiru Bu¹, Meiqing Wu², Wei Cui³, Long Qian³, Zisan Zeng¹, and Muliang Jiang¹

¹Radiology Department of the First Affiliated Hospital of Guangxi Medical University, Nanning, China, ²Hematology Department of The First Affiliated Hospital of Guangxi Medical University, Nanning, China, ³MR Research, GE Healthcare, Beijing, China, Beijing, China

Synopsis

Keywords: White Matter, Blood, Beta-thalassemiaBeta-thalassemia (β-TM) is a genetically haematological disorder leading to reduced production of hemoglobin. Yet its alterations in white matter (WM) microstructure remain unclear. The present study aimed to analyze quantitative MRI parameters of WM in β-TM patients using synthetic MRI. The results showed that T1, T2 and T1/T2 ratio of widespread WM areas were affected by β-TM, which may be related to iron deposition and decrease of myelin concentration. Thus, we concluded that WM alterations in β-TM patients can be revealed by quantitative MRI parameters.

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