Abstract #2646

Central Thalamic Intermittent Theta-Burst Stimulation Ameliorated Memory Impairment in Alzheimer's Disease Mouse Model

Yi-Chen Lin¹, Ssu-Ju Li¹, Yu-Chun Lo², Ting-Chieh Chen¹, Ching-Wen Chang¹, Tsai-Yu Cho¹, Mu-Hua Wang¹, Ching-Te Chen³, Sheng-Huang Lin^4,5, and You-Yin Chen^1,2

¹Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²PhD Program in Medical Neuroscience, Taipei Medical University, Taipei, Taiwan, ³Abbott Neuromodulation, Austin, TX, United States, ⁴Department of Neurology, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ⁵Department of Neurology, Tzu Chi University, Hualien, Taiwan

Synopsis

Keywords: Alzheimer's Disease, fMRI, Intermittent theta-burst stimulation (iTBS)

Intermittent theta-burst stimulation (iTBS) has been hypothesized to be a more effective paradigm for deep brain stimulation (DBS) in treating various neurological disorders by altering neuronal circuits. However, the effect of iTBS in improving memory deficits in AD patients remains unknown. Combining iTBS in central thalamus (CT-iTBS) with functional magnetic resonance imaging, our results demonstrated the restoration of brain functional connectivity (FC) in corticolimbic circuit of AD mice model, accompanied with enhancing memory cognitive function in novel object recognition test and T-maze test. These results revealed that CT-iTBS could be an effective treatment for improving symptoms of individuals with AD.

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