Abstract #2647

Multi-parametric MRI Characterization of the Aging Squirrel Monkey as a Model of Sporadic Cerebral Amyloid Angiopathy

Youssef Z Wadghiri¹, Jelle Veerart¹, Sean Murray¹, Jakub Szabo¹, Carolyn Akers¹, Thomas Genovese¹, Hannah Goldman¹, Jonathan Leung¹, Charles V Kingsley ², Henry Rusinek¹, Stanton Gray², William Donald Hopkins², Thomas Wisniewski¹, and Henrieta Scholtzova¹

¹NYU Grossman School of Medicine, New York, NY, United States, ²UT - MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: Alzheimer's Disease, Aging, Non human primateThe current study seeks to identify neuroimaging biomarkers in a unique squirrel monkey (SQM) as a spontaneous model of cerebral amyloid angiopathy both in vivo and ex vivo using conventional MRI metrics in young and geriatric SQM cohorts and demonstrate the utility of quantitative R2* to map age-related differences in SQM neuropathology cross-sectionally and longitudinally.

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