Abstract #2648
4D Oxy-wavelet MRI and Graph Theory in APOE KO mice: A new perspective into the role of mitochondria and brain connectivity
Devin Raine Everalo Cortes1,2,3,4, Margaret C. Stapleton2,4, Samuel Wyman2,4, Kristina E. Schwab5,6, Noah W. Coulson2,7, Dalton R West2,4, Thomas Becker-Szurszewski5,6, Sean Hartwick5,6, Anthony G. Christodoulou8, and Yijen L Wu2,3,4,9
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 2Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 3Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States, 4Rangos Research Center Small Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 5Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 6Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States, 7Rangos Research Center Small Animal Imaging Core, University of Pittsburgh, Pittsburgh, PA, United States, 8Biomedical Imaging Research Institue, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 9Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Synopsis
Keywords: Alzheimer's Disease, Brain Connectivity, Metabolism, fMRI
Apolipoprotein E (APOE) alleles are strong genetic risk factors for the Late-Onset-Alzheimer’s Disease (LOAD). In this study we utilize our novel 4D Oxy-wavelet functional MRI to study the bioenergetic footprint of APOE knockout (KO) mice compared to wild type (WT) mice. We have created neuronal networks in mice defined by bioenergetic dispersion throughout the whole brain, and demonstrated key differences between APOE KO and WT. We further validate our oxywavelet index for probing mitochondrial function non-invasively and present new signal processing methods for relevant biomarker extraction.
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