Abstract #2649

CADASIL mice are characterized by simultaneous metabolic and vascular stress

Zhiliang Wei^1,2, Yuguo Li^1,2, Lin Chen³, Hongshuai Liu⁴, Minmin Yao⁴, Jiadi Xu^1,2, Angeliki Louvi⁵, Wenzhen Duan^4,6, and Hanzhang Lu^1,2,7

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Electronic Science, Xiamen University, Xiamen, China, ⁴Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Departments of Neurosurgery and Neuroscience, Yale School of Medicine, New Haven, CT, United States, ⁶The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Dementia, AnimalsVascular cognitive impairment and dementia (VCID) is the second leading cause of dementia and is often mixed with other pathologies. Related mouse models with relatively pure vascular pathologies are used for mechanistic studies or therapeutic trials. CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a monogenic condition causing lacunar strokes and vascular dementia. Using the established mouse model of CADASIL, we aimed to investigate potential microvascular dysfunctions with advanced non-contrast MRI techniques. We found that CADASIL mice displayed elevated oxygen consumption and impaired cerebrovascular reactivity, suggesting simultaneous metabolic and vascular stress.

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