Abstract #2650

Metabolic Imaging using Chemical Exchange Saturation Transfer in Rat Transgenic Model of Alzheimer’s Disease Comorbid with Metabolic Syndrome

Dustin Loren Velasco Almanza^1,2, Wilfred Lam², Margaret Koletar², Mary Hill³, JoAnne McLaurin^3,4, Greg Stanisz^1,2, and Bojana Stefanovic^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ⁴Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Alzheimer's Disease, CEST & MTOur study characterized the hippocampal glucose uptake in an Alzheimer’s Disease rat model (TgF344AD) comorbid with metabolic syndrome modeled by cafeteria (CAF) diet. Glucose uptake was evaluated by detecting 2-deoxy-D-glucose (2DG) using chemical exchange saturation transfer (CEST) MRI in 6- and 12-month-old cohorts, reflecting pre-clinical and established disease stages, respectively. CAF diet attenuated glucose uptake of both non-transgenic and transgenic-AD at 6 months of age; whereas at 12 months of age, CAF diet enhanced the hippocampal glucose uptake of TgAD but attenuated it in chow-fed TgAD, when compared to that in correspondingly fed nTg littermates.

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