Abstract #2651

Decreased pH in the mouse brain of Alzheimer’s disease revealed by guanidinium and amide CEST at 3T

Kexin Wang^1,2, Jianpan Huang³, Ziqin Zhang^1,2, Kannie W. Y. Chan^3,4, and Jiadi Xu^2,4

¹Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ⁴Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Alzheimer's Disease, CEST & MT, pH mapping

Guanidinium CEST (GuanCEST) and amideCEST are highly sensitive to pH change, while their correlations with pH are opposite. Thus taking (unitless) difference of GuanCEST and amideCEST provides a reliable indicator for pH. Polynomial and Lorentzian line-shape fitting (PLOF) method helps extract the two CEST signals precisely, and the (unitless) difference shows a significant increase (p=0.008, n=10) in Alzheimer’s disease (AD) mouse brain compared with that of wild type mouse at 3T. Our results light up a novel and promising method to detect the onset of AD noninvasively, bringing the recent breakthrough in AD mechanism to further clinical application.

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