Abstract #2655

Cascade of Perfusion and Brain Atrophy in Alzheimer’s Disease: A Longitudinal Study

Tony Zhou¹, Zongpai Zhang², Arvind Balachandrasekaran³, Cyrus A. Raji⁴, James T. Becker⁵, Lewis H. Kuller⁶, Yulin Ge⁷, Oscar L. Lopez⁸, Weiying Dai², and H. Michael Gach^1,9

¹Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, United States, ²Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ³Boston Children's Hospital, Boston, MA, United States, ⁴Radiology and Neurology, Washington University School of Medicine, Saint Louis, MO, United States, ⁵Psychiatry, Psychology, and Neurology, University of Pittsburgh, Pittsburgh, PA, United States, ⁶Epidemiology, University of Pittsburgh, Pittsburgh, PA, United States, ⁷Radiology, New York University School of Medicine, New York City, NY, United States, ⁸Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States, ⁹Radiology and Biomedical Engineering, Washington University School of Medicine, Saint Louis, MO, United States

Synopsis

Keywords: Alzheimer's Disease, Arterial spin labellingWe conducted a longitudinal study to determine if reduced temporoparietal and frontal cerebral blood flow (CBF) in elderly population leads to reduced gray matter volumes (GMVs) in the temporal lobe, or vice versa. We observed smaller GMVs in the temporal pole (TP) region in Alzheimer’s disease (AD) patients. We also found associations of: (1) the TP GMVs with subsequent temporoparietal CBF declines; (2) the TP CBF with its own subsequent GMV changes; and (3) the hippocampal GMVs with longitudinal frontal CBF declines. Hypoperfusion in the temporal lobe may be an early event driving atrophy, followed by temporoparietal and frontal hypoperfusion.

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