Abstract #2657

Microstructure of the Fornix Correlates with Cognitive Status in Alzheimer’s Disease

Ken Sakaie¹, Katherine Koenig², Jian Lin², Alan Lerner³, James Leverenz⁴, and Mark J. Lowe²

¹The Cleveland Clinic, Cleveland, OH, United States, ²Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States, ³Brain Health and Memory Center, Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁴Lou Ruvo Center for Brain Health, The Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Alzheimer's Disease, DementiaImaging measures of tissue microstructure of the fornix are are potential biomarkers for cognitive decline in Alzheimer’s disease (AD). However, partial volume averaging (PVA) between the fornix and cerobrospinal fluid can be substantial. As a result, measured changes may reflect atrophy, not changes in tissue microstructure. Neurite Orientation Dispersion and Direction Imaging and Free Water Elimination diffusion tensor imaging account for PVA. We present results from a cohort of AD patients, patients with mild cognitive impairment (MCI) and cognitively normal (CN) subjects, showing that NODDI and DTI measures correlate with specific scores cognitive status.

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