Meeting Banner
Abstract #2661

Iron deficiency anemia is associated with abnormal cerebral metabolic rate, blood brain barrier permeability and cognitive function.

Silvie Suriany1, Clio Gonzalez-Zacarias2, Chau Vu2, Sharon ONeil3, Gagan C Mathur4, Dawn C Ward5, Alyssa Ziman5, Ellen B Klapper6, Lefan Zhuang7, and John C Wood1
1Pediatrics, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States, 2University of Southern California, Los Angeles, CA, United States, 3Neuropsychology, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States, 4Transfusion Medicine, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States, 5Transfusion Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 6Transfusion Medicine, Cedar Sinai Medical Center, Los Angeles, CA, United States, 7Transfusion Medicine, City of Hope Medical Center, Duarte, CA, United States

Synopsis

Keywords: Dementia, Metabolism, Iron DeficiencyIron deficiency is the predominant cause of anemia in adults, typically occurring in women with heavy menses, endometriosis or fibroids. We study cerebral metabolic rate of oxygen (CMRO2), blood brain barrier (BBB) permeability to water, and neurocognitive function in 34 women with iron deficiency anemia (IDA). We observed striking deficits in verbal and spatial memory, perceptual reasoning, and crystalized intelligence that were strongly correlated with hemoglobin level. CMRO2 was lower than predicted by anemia alone, correlated to BBB permeability to water, and associated with poorer neurocognitive performance, suggesting decreased brain capillary surface area for oxygen and water diffusion.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords