Abstract #2661

Iron deficiency anemia is associated with abnormal cerebral metabolic rate, blood brain barrier permeability and cognitive function.

Silvie Suriany¹, Clio Gonzalez-Zacarias², Chau Vu², Sharon ONeil³, Gagan C Mathur⁴, Dawn C Ward⁵, Alyssa Ziman⁵, Ellen B Klapper⁶, Lefan Zhuang⁷, and John C Wood¹

¹Pediatrics, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States, ²University of Southern California, Los Angeles, CA, United States, ³Neuropsychology, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States, ⁴Transfusion Medicine, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States, ⁵Transfusion Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁶Transfusion Medicine, Cedar Sinai Medical Center, Los Angeles, CA, United States, ⁷Transfusion Medicine, City of Hope Medical Center, Duarte, CA, United States

Synopsis

Keywords: Dementia, Metabolism, Iron DeficiencyIron deficiency is the predominant cause of anemia in adults, typically occurring in women with heavy menses, endometriosis or fibroids. We study cerebral metabolic rate of oxygen (CMRO₂), blood brain barrier (BBB) permeability to water, and neurocognitive function in 34 women with iron deficiency anemia (IDA). We observed striking deficits in verbal and spatial memory, perceptual reasoning, and crystalized intelligence that were strongly correlated with hemoglobin level. CMRO₂ was lower than predicted by anemia alone, correlated to BBB permeability to water, and associated with poorer neurocognitive performance, suggesting decreased brain capillary surface area for oxygen and water diffusion.

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