Abstract #2664

Associations of the shape of subcortical brain structures with age-related neuropathologies in community-based older adults

Khalid Saifullah¹, Nazanin Makkinejad¹, Arnold M. Evia², David A. Bennett², Julie A. Schneider², and Konstantinos Arfanakis^1,2

¹Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Synopsis

Keywords: Alzheimer's Disease, Neurodegeneration, Aging, AtherosclerosisMultiple age-related neuropathologies lead to atrophy of subcortical brain structures. However, definitive diagnosis of most of these pathologies is only possible at autopsy, complicating investigations into the effects of age-related neuropathologies on the shape of subcortical brain structures. The present work combined ex-vivo MRI and detailed pathologic assessment in a large number (N=842) of community-based older adults to study the relationship between age-related neuropathologies and the shape of subcortical brain structures. The resulting deformation patterns may be used as features in in-vivo classifiers of age-related neuropathologies.

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