Keywords: Alzheimer's Disease, Permeability, DCE-MRI, Low-level Blood-brain-barrier Leakage, Mild cognitive impairmentWe implemented recent developments in DCE-MRI pre-processing and analysis techniques to compare local differences in blood brain barrier (BBB) integrity in subjective memory impairment (SMI) and mild cognitive impairment (MCI), two early indicators of Alzheimer’s disease. Also, as part of the CANN trial, we explored the impact of a combined flavanol and omega-3 fatty acid-based nutritional intervention on BBB leakage. The results show that BBB leakage in memory processing regions can distinguish between SMI and MCI, and thus can be used to quantitatively assess the progress of cSVD towards onset of MCI and/or early indication of Alzheimer’s disease.
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